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What it is: Natural oral micronized (finely ground) progesterone is derived from plant-based sources. Progesterone is important if you haven’t had a hysterectomy (i.e. still have a uterus), and serves as a protective agent for your uterine lining (endometrium). If estrogen is taken without progesterone, it can lead to excessive growth of the uterine lining and put you at risk for endometrial cancer.
How it works: Natural micronized progesterone is taken orally, and can be prescribed to be taken either for 12 days every one-to-two months or else on a daily dose. Your EverNow doctor will help you decide which prescription is right for you. Cyclic progesterone promotes shedding of the endometrium, mimicking the same process that you experience during your menstrual cycle. Daily progesterone prevents the uterine lining from growing at all. Both forms of progesterone administration are effective at preventing endometrial hyperplasia and uterine cancers.
What the research says: A 2016 systematic review determined that oral micronized progesterone provides endometrial protection from abnormal thickening (endometrial hyperplasia) and endometrial cancer.
Brand name: Prometrium pills; Evernow uses the generic micronized progesterone tablets.
Range of dosage: 100mg orally daily, or 200 mg daily for 12 days every 2 months.
Safety information: If you have had a hysterectomy or vaginal bleeding that has not been evaluated by a doctor, a previous stroke or heart attack or currently have or have had blood clots or liver problems, progesterone may not be right for you. You should speak to your in-person care provider to determine your best treatment options. To learn more about the risks and benefits of micronized progesterone and to read the boxed warning, see this Prometrium safety information.